Publications

2015

Glutamine synthetase activity fuels nucleotide biosynthesis and supports growth of glutamine-restricted glioblastoma.

Tardito S, Oudin A, Ahmed SU, Fack F, Keunen O, Zheng L, Miletic H, Sakariassen PO, Weinstock A, Wagner A, Lindsay SL, Hock AK, Barnett SC, Ruppin E, Morkve SH, Lund-Johansen M, Chalmers AJ, Bjerkvig R, Niclou SP, Gottlieb E. Nat Cell Biol. 2015. [Epub ahead of print].

Comprehensive analysis of glycolytic enzymes as therapeutic targets in the treatment of glioblastoma.

Sanzey M, Abdul Rahim SA, Oudin A, Dirkse A, Kaoma T, Vallar L, Herold-Mende C, Bjerkvig R, Golebiewska A, Niclou SP. PLoS One. 2015 May 1;10(5):e0123544. doi: 10.1371/journal.pone.0123544. eCollection 2015.

Inference of low and high-grade glioma gene regulatory networks delineates the role of Rnd3 in establishing multiple hallmarks of cancer.

Clarke K, Daubon T, Turan N, Soulet F, Mohd Zahari M, Ryan KR, Durant S, He S, Herbert J, Ankers J, Heath JK, Bjerkvig R, Bicknell R, Hotchin NA, Bikfalvi A, Falciani F. 2015 Jul. PLoS Genet.11(7):e1005325.

Epigenetic activity of peroxisome proliferator-activated receptor gamma agonists increases the anticancer effect of histone deacetylase inhibitors on multiple myeloma cells.

Aouali N, Broukou A, Bosseler M, Keunen O, Schlesser V, Janji B, Palissot V, Stordeur P, Berchem G. 2015 Jun. PLoS One.10(6):e0130339.

Cardiometabolic risk: leg fat is protective during childhood.

Samouda H, De Beaufort C, Stranges S, Hirsch M, Van Nieuwenhuyse JP, Dooms G, Gilson G, Keunen O, Leite S, Vaillant M, Lair ML, Dadoun F. Pediatr Diabetes. 2016 Jun;17(4):300-8. doi: 10.1111/pedi.12292. Epub 2015 Jun 17.

Gauging heterogeneity in primary versus recurrent glioblastoma.

Niclou SP. 2015 May. Neuro Oncol. [Epub ahead of print].

Permanent culture of macrophages at physiological oxygen attenuates the antioxidant and immunomodulatory properties of dimethyl fumarate.

Haas B, Chrusciel S, Fayad-Kobeissi S, Dubois-Rande JL, Azuaje F, Boczkowski J, Motterlini R, Foresti R. 2015 May. J Cell Physiol.230(5):1128-38.

Therapeutic control and resistance of the EGFR-driven signaling network in glioblastoma.

Azuaje F, Tiemann K, Niclou SP. 2015 Mar. Cell Commun Signal.13(1):23.

Melanoma brain metastasis is independent of lactate dehydrogenase A expression.

Sundstrom T, Espedal H, Harter PN, Fasmer KE, Skaftnesmo KO, Horn S, Hodneland E, Mittelbronn M, Weide B, Beschorner R, Bender B, Rygh CB, Lund-Johansen M, Bjerkvig R, Thorsen F. 2015 Mar. Neuro Oncol. [Epub ahead of print].

Whole genomes redefine the mutational landscape of pancreatic cancer.

Waddell N, Pajic M, Patch AM, Chang DK, Kassahn KS, Bailey P, Johns AL, Miller D, Nones K, Quek K, Quinn MC, Robertson AJ, Fadlullah MZ, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, Manning S, Nourse C, Nourbakhsh E, Wani S, Wilson PJ, Markham E, Cloonan N, Anderson MJ, Fink JL, Holmes O, Kazakoff SH, Leonard C, Newell F, Poudel B, Song S, Taylor D, Waddell N, Wood S, Xu Q, Wu J, Pinese M, Cowley MJ, Lee HC, Jones MD, Nagrial AM, Humphris J, Chantrill LA, Chin V, Steinmann AM, Mawson A, Humphrey ES, Colvin EK, Chou A, Scarlett CJ, Pinho AV, Giry-Laterriere M, Rooman I, Samra JS, Kench JG, Pettitt JA, Merrett ND, Toon C, Epari K, Nguyen NQ, Barbour A, Zeps N, Jamieson NB, Graham JS, Niclou SP, Bjerkvig R, Grutzmann R, Aust D, Hruban RH, Maitra A, Iacobuzio-Donahue CA, Wolfgang CL, Morgan RA, Lawlor RT, Corbo V, Bassi C, Falconi M, Zamboni G, Tortora G, Tempero MA, Gill AJ, Eshleman JR, Pilarsky C, Scarpa A, Musgrove EA, Pearson JV, Biankin AV, Grimmond SM. 2015 Feb. Nature.518(7540):495-501.

Axitinib increases the infiltration of immune cells and reduces the suppressive capacity of monocytic MDSCs in an intracranial mouse melanoma model.

Four SD, Maenhout SK, De Pierre K, Renmans D, Niclou SP, Thielemans K, Neyns B, Aerts JL. 2015 Jan. Oncoimmunology.4(4):e998107.

A gene mapping bottleneck in the translational route from zebrafish to human.

de Klein N, Ibberson M, Crespo I, Rodius S, Azuaje F. 2015 Jan. Front Genet.5:470.

Bevacizumab treatment induces metabolic adaptation toward anaerobic metabolism in glioblastomas.

Fack F, Espedal H, Keunen O, Golebiewska A, Obad N, Harter PN, Mittelbronn M, Bahr O, Weyerbrock A, Stuhr L, Miletic H, Sakariassen PO, Stieber D, Rygh CB, Lund-Johansen M, Zheng L, Gottlieb E, Niclou SP, Bjerkvig R. 2015 Jan. Acta Neuropathol.129(1):115-31. Epub 2014 Oct 17.