Odoo Members
Photo: (from left to right) Dr Carlo Bock, Dr Anne Schuster, Prof Dr Simone Niclou, Dr Gregor Baertz, Martine Neyen.

The Cancer Foundation supports a research project of the NorLux Neuro-Oncology Laboratory

The Cancer Foundation (Fondation Cancer) funds a research project of the NorLux Neuro-Oncology Laboratory entitled ‘targeting glioma cell invasion’ which aims at unravelling the mechanisms underlying cancer cell invasion in glioblastoma (glioma, malignant brain tumours) and at proposing new therapeutic strategies to block tumour progression.

On 28th  January 2015, Dr Carlo Bock, president of the Cancer Foundation and Martine Neyen, Director of the Cancer Foundation, handed over a check of 397,104 € to laboratory head Prof Dr Simone Niclou and postdoctoral researcher Dr Anne Schuster in the presence of Dr Gregor Baertz, president of the board of directors of the Luxembourg Institute of Health (LIH).

Glioblastomas are the most common and also the most aggressive brain tumours. They are diagnosed most frequently in patients aged between 45 and 70. The tumours have the ability to cause bulky lesions, to deeply penetrate into the brain tissue and even to progress from one hemisphere to the other. This invasive character prevents complete surgical removal. Recurrence can thus rarely be avoided and current treatments have limited efficiency.

In the frame of the research project, Prof Dr Niclou and her team aim to identify key genes involved in glioblastoma invasion. To this end, Dr Schuster will conduct a high-throughput genome-wide RNA interference screen. The identified candidate genes will further be tested for their role in the invasion process by robust in vitro  and in vivo experiments using a reliable glioblastoma mouse model. This ambitious project should ultimately lead to new therapeutic approaches that effectively inhibit tumour growth. The team hopes to be able to provide a better perspective to patients soon.